Real-time microscopic visualization of tissue response to laser thermal therapy

Benjamin J. Vakoc; Guillermo J. Tearney M.D.; Brett E. Bouma

doi:10.1117/1.2714027

1 March 2007 Real-time microscopic visualization of tissue response to laser thermal therapy

Benjamin J. Vakoc, Guillermo J. Tearney M.D., Brett E. Bouma

Author Affiliations +

Journal of Biomedical Optics, Vol. 12, Issue 2, 020501 (March 2007). https://doi.org/10.1117/1.2714027

Abstract

We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution (~10 µm) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Benjamin J. Vakoc, Guillermo J. Tearney M.D., and Brett E. Bouma "Real-time microscopic visualization of tissue response to laser thermal therapy," Journal of Biomedical Optics 12(2), 020501 (1 March 2007). https://doi.org/10.1117/1.2714027

Published: 1 March 2007

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY