Design of a handheld optical coherence microscopy endoscope

Vrushali R. Korde; Jennifer K. Barton; Erica Liebmann

doi:10.1117/1.3594149

1 June 2011 Design of a handheld optical coherence microscopy endoscope

Vrushali R. Korde, Jennifer K. Barton, Erica Liebmann

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 6, 066018 (June 2011). https://doi.org/10.1117/1.3594149

Abstract

Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve laterally a 1.4-μm line pair feature and has an axial resolution (full width half maximum) of 5.4 μm. Images taken with this endoscope of fresh ex-vivo mouse ovaries show structural features, such as corpus luteum, primary follicles, growing follicles, and fallopian tubes. This rigid handheld OCM endoscope can be useful for a variety of minimally invasive and surgical imaging applications.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Vrushali R. Korde, Jennifer K. Barton, and Erica Liebmann "Design of a handheld optical coherence microscopy endoscope," Journal of Biomedical Optics 16(6), 066018 (1 June 2011). https://doi.org/10.1117/1.3594149

Published: 1 June 2011

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KEYWORDS

Endoscopes

Ovary

Tissue optics

Tissues

Tolerancing

Optical coherence microscopy

Mirrors

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