Deep-tissue light delivery via optrode arrays

Tanya Vanessa F. Abaya; Mohit Diwekar; Steve Blair; Prashant Tathireddy; Loren Rieth; Florian Solzbacher

doi:10.1117/1.JBO.19.1.015006

9 January 2014 Deep-tissue light delivery via optrode arrays

Tanya Vanessa F. Abaya, Mohit Diwekar, Steve Blair, Prashant Tathireddy, Loren Rieth, Florian Solzbacher

Author Affiliations +

Funded by: University of Utah Research Foundation and NSF, National Science Foundation (NSF), NSF MRSEC, University of Utah

Journal of Biomedical Optics, Vol. 19, Issue 1, 015006 (January 2014). https://doi.org/10.1117/1.JBO.19.1.015006

Abstract

We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths <1 mm . Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is ∼3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 μm and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation.

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Tanya Vanessa F. Abaya, Mohit Diwekar, Steve Blair, Prashant Tathireddy, Loren Rieth, and Florian Solzbacher "Deep-tissue light delivery via optrode arrays," Journal of Biomedical Optics 19(1), 015006 (9 January 2014). https://doi.org/10.1117/1.JBO.19.1.015006

Published: 9 January 2014

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