Detecting structural information of scatterers using spatial frequency domain imaging

Nico Bodenschatz; Philipp Krauter; Steffen Nothelfer; Florian Foschum; Florian Bergmann; André Liemert; Alwin Kienle

doi:10.1117/1.JBO.20.11.116006

23 November 2015 Detecting structural information of scatterers using spatial frequency domain imaging

Nico Bodenschatz, Philipp Krauter, Steffen Nothelfer, Florian Foschum, Florian Bergmann, André Liemert, Alwin Kienle

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Journal of Biomedical Optics, Vol. 20, Issue 11, 116006 (November 2015). https://doi.org/10.1117/1.JBO.20.11.116006

Abstract

We demonstrate optical phantom experiments on the phase function parameter γ using spatial frequency domain imaging. The incorporation of two different types of scattering particles allows for control of the optical phantoms’ microscopic scattering properties. By laterally structuring areas with either TiO₂ or Al2O₃ scattering particles, we were able to obtain almost pure subdiffusive scattering contrast in a single optical phantom. Optical parameter mapping was then achieved using an analytical radiative transfer model revealing the microscopic structural contrast on a macroscopic field of view. As part of our study, we explain several correction and referencing techniques for high spatial frequency analysis and experimentally study the sampling depth of the subdiffusive parameter γ.

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Nico Bodenschatz, Philipp Krauter, Steffen Nothelfer, Florian Foschum, Florian Bergmann, André Liemert, and Alwin Kienle "Detecting structural information of scatterers using spatial frequency domain imaging," Journal of Biomedical Optics 20(11), 116006 (23 November 2015). https://doi.org/10.1117/1.JBO.20.11.116006

Published: 23 November 2015

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