In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy

Rolf B. Saager; Ata Sharif M.D.; Kristen M. Kelly M.D.; Anthony J. Durkin

doi:10.1117/1.JBO.21.5.057001

3 May 2016 In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy

Rolf B. Saager, Ata Sharif M.D., Kristen M. Kelly M.D., Anthony J. Durkin

Author Affiliations +

Funded by: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), National Institutes of Health, NIH, National Institute of Health, NIH/NIBIB, Beckman Foundation and the NIH, NIH (NIBIB) Laser Microbeam and Medical Program, NIBIB Biomedical Technology Research Center LAMMP, NIH NIBIB Biomedical Technology Research Center LAMMP, NIH/NIBIB funded LAMMP, US National Institutes of Health (NIH), National Institute of Biomedical Imaging and Bioengineering, Arnold & Mabel Beckman Foundation, National Institute of Biomedical Imaging Bioengineering, NIH NIBIB, NIBIB, NIGMS

Journal of Biomedical Optics, Vol. 21, Issue 5, 057001 (May 2016). https://doi.org/10.1117/1.JBO.21.5.057001

Abstract

Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Rolf B. Saager, Ata Sharif M.D., Kristen M. Kelly M.D., and Anthony J. Durkin "In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy," Journal of Biomedical Optics 21(5), 057001 (3 May 2016). https://doi.org/10.1117/1.JBO.21.5.057001

Published: 3 May 2016

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY