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10 November 2017 Coagulation measurement from whole blood using vibrating optical fiber in a disposable cartridge
Yusuf Samet Yaraş, Ali Bars Gündüz, Gökhan Sağlam, Selim Ölçer, Fehmi Civitçi, İbrahim Baris, Göksenin Yaralioğlu, Hakan Urey
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Funded by: TÜBİTAK
Journal of Biomedical Optics, Vol. 22, Issue 11, 117001 (November 2017). https://doi.org/10.1117/1.JBO.22.11.117001
Abstract
In clinics, blood coagulation time measurements are performed using mechanical measurements with blood plasma. Such measurements are challenging to do in a lab-on-a-chip (LoC) system using a small volume of whole blood. Existing LoC systems use indirect measurement principles employing optical or electrochemical methods. We developed an LoC system using mechanical measurements with a small volume of whole blood without requiring sample preparation. The measurement is performed in a microfluidic channel where two fibers are placed inline with a small gap in between. The first fiber operates near its mechanical resonance using remote magnetic actuation and immersed in the sample. The second fiber is a pick-up fiber acting as an optical sensor. The microfluidic channel is engineered innovatively such that the blood does not block the gap between the vibrating fiber and the pick-up fiber, resulting in high signal-to-noise ratio optical output. The control plasma test results matched well with the plasma manufacturer’s datasheet. Activated-partial-thromboplastin-time tests were successfully performed also with human whole blood samples, and the method is proven to be effective. Simplicity of the cartridge design and cost of readily available materials enable a low-cost point-of-care device for blood coagulation measurements.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Yusuf Samet Yaraş, Ali Bars Gündüz, Gökhan Sağlam, Selim Ölçer, Fehmi Civitçi, İbrahim Baris, Göksenin Yaralioğlu, and Hakan Urey "Coagulation measurement from whole blood using vibrating optical fiber in a disposable cartridge," Journal of Biomedical Optics 22(11), 117001 (10 November 2017). https://doi.org/10.1117/1.JBO.22.11.117001
Received: 15 March 2017; Accepted: 12 October 2017; Published: 10 November 2017
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Cited by 5 scholarly publications.
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KEYWORDS
Blood
Optical fibers
Plasma
Microfluidics
Control systems
Signal to noise ratio
Sensors
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