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22 February 2018 Benchtop and animal validation of a portable fluorescence microscopic imaging system for potential use in cholecystectomy
Jian Ye, Guanghui Liu, Peng Liu, Shiwu Zhang, Pengfei Shao, Zachary J. Smith, Chenhai Liu, Ronald X. Xu
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Journal of Biomedical Optics, Vol. 23, Issue 2, 020504 (February 2018). https://doi.org/10.1117/1.JBO.23.2.020504
Abstract
We propose a portable fluorescence microscopic imaging system (PFMS) for intraoperative display of biliary structure and prevention of iatrogenic injuries during cholecystectomy. The system consists of a light source module, a camera module, and a Raspberry Pi computer with an LCD. Indocyanine green (ICG) is used as a fluorescent contrast agent for experimental validation of the system. Fluorescence intensities of the ICG aqueous solution at different concentration levels are acquired by our PFMS and compared with those of a commercial Xenogen IVIS system. We study the fluorescence detection depth by superposing different thicknesses of chicken breast on an ICG-loaded agar phantom. We verify the technical feasibility for identifying potential iatrogenic injury in cholecystectomy using a rat model in vivo. The proposed PFMS system is portable, inexpensive, and suitable for deployment in resource-limited settings.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
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Jian Ye, Guanghui Liu, Peng Liu, Shiwu Zhang, Pengfei Shao, Zachary J. Smith, Chenhai Liu, and Ronald X. Xu "Benchtop and animal validation of a portable fluorescence microscopic imaging system for potential use in cholecystectomy," Journal of Biomedical Optics 23(2), 020504 (22 February 2018). https://doi.org/10.1117/1.JBO.23.2.020504
Received: 10 October 2017; Accepted: 19 January 2018; Published: 22 February 2018
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KEYWORDS
Luminescence
Imaging systems
Injuries
Light sources
In vivo imaging
Light emitting diodes
Tissues
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