Optimized depth-resolved estimation to measure optical attenuation coefficients from optical coherence tomography and its application in cerebral damage determination

Jian Liu; Ning Ding; Yao Yu; Xincheng Yuan; Shuzhuo Luo; Jingmin Luan; Yuqian Zhao; Yi Wang; Zhenhe Ma

doi:10.1117/1.JBO.24.3.035002

4 March 2019 Optimized depth-resolved estimation to measure optical attenuation coefficients from optical coherence tomography and its application in cerebral damage determination

Jian Liu, Ning Ding, Yao Yu, Xincheng Yuan, Shuzhuo Luo, Jingmin Luan, Yuqian Zhao, Yi Wang, Zhenhe Ma

Author Affiliations +

Funded by: National Natural Science Foundation of China (NSFC), Hebei Provincial Natural Science Foundation of China, Natural Science Foundation of Hebei Province (Hebei Provincial Natural Science Foundation), Fundamental Research Funds for the Central Universities

Journal of Biomedical Optics, Vol. 24, Issue 3, 035002 (March 2019). https://doi.org/10.1117/1.JBO.24.3.035002

Abstract

The optical attenuation coefficient (OAC) reflects the optical properties of various tissues or tissues of the same type under different physiological conditions. Quantitative measurement of OAC from optical coherence tomography (OCT) signals can provide additional information and can increase the potential for OCT applications. We present an optimized depth-resolved estimation (ODRE) method that derives a precise mapping between the measured OCT signal and the OAC. In contrast to previous depth-resolved estimation (DRE) methods, the optimized method can estimate the OAC in any depth range and ignore whether the light is completely attenuated. Numerical simulations and phantom experiments are used to verify its validity, and this method is applied to detect cerebral damage. In combination with OCT angiography, real-time observation of the change of blood perfusion and the degree of cerebral damage in mice with focal cerebral ischemia provides important information to help us understand the temporal relationship between brain damage and ischemia.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jian Liu, Ning Ding, Yao Yu, Xincheng Yuan, Shuzhuo Luo, Jingmin Luan, Yuqian Zhao, Yi Wang, and Zhenhe Ma "Optimized depth-resolved estimation to measure optical attenuation coefficients from optical coherence tomography and its application in cerebral damage determination," Journal of Biomedical Optics 24(3), 035002 (4 March 2019). https://doi.org/10.1117/1.JBO.24.3.035002

Received: 31 August 2018; Accepted: 14 February 2019; Published: 4 March 2019

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