Spatial landscape of oxygen in and around microvasculature during epileptic events

Cong Zhang; Mohammad Moeini; Frédéric Lesage

doi:10.1117/1.NPh.4.1.010501

11 March 2017 Spatial landscape of oxygen in and around microvasculature during epileptic events

Cong Zhang, Mohammad Moeini, Frédéric Lesage

Author Affiliations +

Neurophotonics, Vol. 4, Issue 1, 010501 (March 2017). https://doi.org/10.1117/1.NPh.4.1.010501

Abstract

Measuring changes in cerebral oxygen in tissue microdomains during epilepsy is important to identify hypoxic potential. Here, using a custom-built two-photon microscopy system, we present microscopic measurements of oxygen partial pressure (PO2) in cortical microvessels and tissue of anesthetized mice during 4-aminopyridine (4-AP)-induced epileptic seizures. Investigating epileptic events, we characterized the distribution of the “initial dip” in PO2 in arterioles, venules, and tissue near the 4-AP injection site. Our results reveal a correlation between the percent change in PO2 during the “initial dip” and the diameter of nearest arterioles and venules.

Citation Download Citation

Cong Zhang, Mohammad Moeini, and Frédéric Lesage "Spatial landscape of oxygen in and around microvasculature during epileptic events," Neurophotonics 4(1), 010501 (11 March 2017). https://doi.org/10.1117/1.NPh.4.1.010501

Received: 31 October 2016; Accepted: 17 February 2017; Published: 11 March 2017

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY