Dr. Aizhong Zhang Profile

Dr. Aizhong Zhang

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Publications (2)

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SPIE Press Book | 24 September 2021

Review of Optical Manufacturing 2000 to 2020

KEYWORDS: Glasses, Optics manufacturing, Polymers, Coating, Metrology, Photonics, Polishing, Silica, Optical components, Refractive index

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This book summarizes some of the critical changes that have impacted optical system manufacturing from 2000 to 2020. It evaluates new manufacturing techniques with growing popularity and identifies future trends. The chapters provide a snapshot of the field that conveys the basics of current manufacturing capabilities and promising new techniques. Other topics reviewed include optical materials, optical fabrication, metrology, optical coatings, infrared optical systems, polymer optics, fiber optics, diffractive- and micro-structured optics, and illumination optics. This book is suitable for beginner optical engineers learning about the optics industry and for advanced professionals staying up-to-date with various subfields of optics.

Review of Optical Manufacturing 2000 to 2020

Proceedings Article | 7 March 2016 Paper

Multimodal imaging of ocular surface of dry eye subjects

Aizhong Zhang, Gheorghe Salahura, Ranjini Kottaiyan, Geunyoung Yoon, James Aquavella, James Zavislan

Proceedings Volume 9701, 97010H (2016) https://doi.org/10.1117/12.2205263

KEYWORDS: Eye, Principal component analysis, Infrared cameras, Thermography, Cameras, Long wavelength infrared, Infrared radiation, Statistical analysis, Multimodal imaging, Video

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To study the relationship between the corneal lipid layer and the ocular surface temperature (OST), we conducted a clinical trial for 20 subjects. Subjects were clinically screened prior to the trial. Of the 20 subjects, 15 have Meibomian gland dysfunction (MGD), and 5 have aqueous-deficient dry eye (ADDE). A custom, circularly polarized illumination video tearscope measured the lipid layer thickness of the ocular tear film. A long-wave infrared video camera recorded the dynamic thermal properties of the ocular team film. The results of these two methods were analyzed and compared. Using principal component analysis (PCA) of the lipid layer distribution, we find that the 20 subjects could be categorized into five statistically significant groups, independent of their original clinical classification: thin (6 subjects), medium (5 subjects), medium and homogenous (3 subjects), thick (4 subjects), and very thick (2 subjects) lipids, respectively. We also conducted PCA of the OST data, and recategorized the subjects into two thermal groups by k-means clustering: one includes all ADDE subjects and some MGD subjects; the other includes the remaining MGD subjects. By comparing these two methods, we find that dry eye subjects with thin (≤ 40 nm) lipids have significantly lower OST, and a larger OST drop range, potentially due to more evaporation. However, as long as the lipid layer is not thin (> 40 nm), there is no strong correlation between the lipid layer thickness and heterogeneity and the OST patterns.

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