Dr. Antonio Giulietti Profile

Dr. Antonio Giulietti

assiciate scientist at Istituto Nazionale di Ottica / CNR

SPIE Involvement:

Author

Proceedings Article | 18 April 2021 Presentation

Perspectives for effective applications of laser-driven Very High Energy Electrons in medicine and biology

Luca Labate, Daniele Palla, Daniele Panetta, M. Avella, Federica Baffigi, Fernando Brandi, Fabio Di Martino, Lorenzo Fulgentini, Antonio Giulietti, Petra Koester, Davide Terzani, Paolo Tomassini, Claudio Traino, Leonida Gizzi

Proceedings Volume 11790, 1179009 (2021) https://doi.org/10.1117/12.2596504

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The direct use of so-called Very High Energy Electrons for radiotherapy is currently deserving a renewed and growing attention. This is mostly due to the recent emergence of the so-called FLASH effect in radiobiology [1], consisting in a surprising reduction of adverse effects on healthy tissue by ionizing radiation when dose delivery occurs at very high average dose rates (greater than a few tens of Gy/s). In order for a real clinical translation of this new protocol in the clinical practice, the development of novel kind of ionizing radiation sources featuring such very high dose rates, which are basically hindered by the relatively low Bremsstrahlung conversion efficiency in current machines, is considered as an essential step. With this respect, laser-driven accelerators of Very High Energy Electron (VHEE) beams, with energy in the range 100-250 MeV, are regarded as one of the most promising tool [2]. Furthermore, both early studies, dating back to 1990s, and more recent works suggest that an improved dose deposition pattern can be expected from electron beams, as compared to photon beams, when the very high energy region is reached. In this talk, we report on a recent experiment aimed at assessing dose deposition for deep seated tumors using advanced irradiation schemes, typical of current radiotherapy protocols, with an existing laser-driven VHEE source [3]. In particular, our measurements showed control of localized dose deposition and modulation, suitable to target a volume at depths in the range from 5 to 10 cm with mm resolution. Based on this experimental findings and on further numerical simulations, we also discuss the features and potentialities of laser-driven VHEE sources for radiobiology experiments aimed at deepening the understanding of the mechanisms underpinning the FLASH effect. The main requirements and the perspectives for a longer term translation of an electron-based radiotherapy into the real clinical practice will be also addressed. [1] M.-C. Vozenin et al., Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken, Clin. Oncol. 31 (2019), 407 [2] A. Giulietti (Eds), Laser-Driven Particle Acceleration Towards Radiobiology and Medicine, Springer (2016) [3] L. Labate et al., Toward an effective use of laser‐driven very high energy electrons for radiotherapy: Feasibility assessment of multi‐field and intensity modulation irradiation schemes, Sci. Rep. 10 (2020), 17307

Proceedings Article | 16 May 2017 Paper

Laser-driven particle acceleration for radiobiology and radiotherapy: where we are and where we are going

Antonio Giulietti

Proceedings Volume 10239, 1023904 (2017) https://doi.org/10.1117/12.2270945

KEYWORDS: Radiotherapy, Particles, Tumors, Electrons, Tissues, Plasma, Prototyping, Reliability

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Proceedings Article | 7 May 2013 Paper

Small-scale laser based electron accelerators for biology and medicine: a comparative study of the biological effectiveness

Luca Labate, Maria Grazia Andreassi, Federica Baffigi, Giuseppina Basta, Ranieri Bizzarri, Andrea Borghini, Giuliana Candiano, Carlo Casarino, Monica Cresci, Fabio Di Martino, Lorenzo Fulgentini, Francesco Ghetti, Maria Carla Gilardi, Antonio Giulietti, Petra Köster, Francesco Lenci, Tadzio Levato, Yuji Oishi, Giorgio Russo, Antonella Sgarbossa, Claudio Traino, Leonida Gizzi

Proceedings Volume 8779, 87790O (2013) https://doi.org/10.1117/12.2019689

KEYWORDS: Laser applications, Monte Carlo methods, Plasmas, Double sideband modulation, Biology, Medicine, Electroluminescent displays, Radiotherapy, Particles, Proteins

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Proceedings Article | 9 June 2011 Paper

Investigation of laser plasmas relevant to shock ignition at PALS

J. Nejdl, M. Kozlová, M. Sawicka, D. Margarone, M. Krus, J. Prokupek, B. Rus, D. Batani, L. Antonelli, A. Patria, O. Ciricosta, C. Cecchetti, P. Koester, L. Labate, A. Giulietti, L. Gizzi, A. Moretti, M. Richetta, G. Schurtz, X. Ribeyre, M. Lafon, C. Spindloe, T. O'Dell

Proceedings Volume 8080, 80802B (2011) https://doi.org/10.1117/12.892321

KEYWORDS: Plasmas, Electrons, Pulsed laser operation, Spectroscopy, X-rays, Charge-coupled devices, Crystals, Fusion energy, Laser scattering, Laser energy

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Proceedings Article | 9 June 2011 Paper

Parametric instabilities study in a shock ignition relevant regime

C. Cecchetti, A. Giulietti, P. Koester, L. Labate, T. Levato, L. Gizzi, L. Antonelli, A. Patria, D. Batani, M. Kozlová, D. Margarone, J. Nejdl, B. Rus, M. Sawicka, M. Lafon, X. Ribeyre, G. Schurtz

Proceedings Volume 8080, 80802A (2011) https://doi.org/10.1117/12.891249

KEYWORDS: Plasma, Electrons, Fusion energy, Pulsed laser operation, Diagnostics, Laser energy, Laser scattering, Raman scattering, Laser systems engineering, Scattering

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Proceedings Article | 26 May 2011 Paper

Pulsed radiobiology with laser-driven plasma accelerators

Antonio Giulietti, Maria Grazia Andreassi, Carlo Greco

Proceedings Volume 8079, 80791J (2011) https://doi.org/10.1117/12.888736

KEYWORDS: Plasma, Pulsed laser operation, Radiotherapy, Monte Carlo methods, Ionizing radiation, Data modeling, Proteins, Laser systems engineering, Femtosecond phenomena, Oncology

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Proceedings Article | 23 May 2007 Paper

Optimization and control of bright, ultrafast laser driven x-ray sources

L. Gizzi, A. Giulietti, D. Giulietti, P. Koester, L. Labate, T. Levato, F. Zamponi, T. Kämpfer, I. Uschmann, E. Förster, R. Sauerbrey

Proceedings Volume 6634, 66341H (2007) https://doi.org/10.1117/12.742103

KEYWORDS: Electrons, X-rays, X-ray sources, Femtosecond phenomena, Titanium, Solids, Pulsed laser operation, Charge-coupled devices, Aluminum, Signal detection

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Proceedings Article | 23 May 2007 Paper

Novel types of ionizing radiation sources at LNF-PLASMONX facility

Danilo Giulietti, Antonio Giulietti, Leonida Gizzi, Paolo Tomassini, Luca Serafini, Vittoria Petrillo, Cristina Vaccarezza, Massimo Ferrario, Piernicola Oliva, Simone Stumbo, Pasquale Delogu, Ubaldo Bottigli, Sergio Bertolucci, Mario Calvetti

Proceedings Volume 6634, 66341F (2007) https://doi.org/10.1117/12.742090

KEYWORDS: Electrons, X-rays, Ionizing radiation, Ion beams, Plasma, Diagnostics, Cancer, Ions, Laser scattering, Tissues

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Proceedings Article | 23 May 2007 Paper

Production of plasma channels in gas-jets

A. Gamucci, M. Galimberti, D. Giulietti, L. Gizzi, T. Hosokai, L. Labate, C. Petcu, P. Tomassini, A. Giulietti

Proceedings Volume 6634, 66341J (2007) https://doi.org/10.1117/12.742063

KEYWORDS: Plasma, Electrons, Pulsed laser operation, Helium, Interferometry, Wave propagation, Femtosecond phenomena, Prisms, Gases, Fringe analysis

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Proceedings Article | 7 December 2006 Paper

R&D on high energy photonics at the Intense Laser Irradiation Laboratory

Antonio Giulietti, Marco Galimberti, Danilo Giulietti, Leonida Gizzi, Petra Koester, Luca Labate, Paolo Tomassini, Moreno Vaselli

Proceedings Volume 5974, 59740M (2006) https://doi.org/10.1117/12.639995

KEYWORDS: X-rays, Electrons, Plasmas, Photons, Pulsed laser operation, Crystals, X-ray sources, Laser scattering, Absorption, Thomson scattering

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Proceedings Article | 23 April 2001 Paper

Gamma-ray measurements in relativistic interaction with underdense plasmas

M. Galimberti, Antonio Giulietti, Danilo Giulietti, L. Gizzi, M. Borghesi, H. Campbell, A. Schiavi, Oswald Willi

Proceedings Volume 4424, (2001) https://doi.org/10.1117/12.425545

KEYWORDS: Electrons, Plasmas, Gamma radiation, Pulsed laser operation, Picosecond phenomena, Sensors, Crystals, Fusion energy, Scintillators, Interferometry

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Proceedings Article | 23 April 2001 Paper

High-order harmonic generation and attosecond pulse production from a linear chain of ions

R. Numico, Danilo Giulietti, Antonio Giulietti, L. Gizzi, Luis Roso

Proceedings Volume 4424, (2001) https://doi.org/10.1117/12.425650

KEYWORDS: Ions, Chemical species, Harmonic generation, Ionization, Systems modeling, High harmonic generation, Pulsed laser operation, Complex systems, Molecules, Motion models

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Proceedings Article | 1 October 1991 Paper

Plasma interaction with powerful laser beams

Antonio Giulietti, Danilo Giulietti, Oswald Willi

Proceedings Volume 1502, (1991) https://doi.org/10.1117/12.46901

KEYWORDS: Plasma, High power lasers, X-rays, Plasmons, Laser welding, Modulation, Harmonic generation, Physics, Backscatter, Picosecond phenomena

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Proceedings Article | 1 September 1991 Paper

L-shell x-ray spectroscopy of laser-produced plasmas in the 1-keV region

Dimitri Batani, Antonio Giulietti, Libero Palladino, Gregory Tallents, I. C. Edmond Turcu

Proceedings Volume 1503, (1991) https://doi.org/10.1117/12.46959

KEYWORDS: Iron, X-rays, Copper, Plasmas, Crystals, Tellurium, Beryllium, Optical filters, Excimer lasers, Neodymium

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Proceedings Article | 1 August 1990 Paper

Atmospheric pressure operation of a repetitive KrF laser-plasma x-ray source at hv = 1.1 keV

I. C. Edmond Turcu, Fergus O'Neill, Gregory Tallents, T. Hannon, Dimitri Batani, Antonio Giulietti, C. Wharton, R. Meldrum

Proceedings Volume 1278, (1990) https://doi.org/10.1117/12.20614

KEYWORDS: Helium, Copper, X-rays, Plasma, Pulsed laser operation, Atmospheric plasma, Beryllium, Excimer lasers, Photons, Optical filters

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Showing 5 of 15 publications

SPIE Conference Volume | 10 July 2017

Medical Applications of Laser-Generated Beams of Particles IV: Review of Progress and Strategies for the Future

Conference Committee Involvement (7)

Applying Laser-driven Particle Acceleration III: Uses of Distinctive Energetic Particle and Photon Sources

24 April 2023 | Prague, Czech Republic

Applying Laser-driven Particle Acceleration II, Medical and Nonmedical Uses of Distinctive Energetic Particle and Photon Sources: SPIE Optics + Optoelectronics Industry Event

19 April 2021 | Online Only, Czech Republic

Applying Laser-driven Particle Acceleration Workshop: Using Distinctive Energetic Particle and Photon Sources

2 April 2019 | Prague, Czech Republic

Medical Applications of Laser-Generated Beams of Particles: Review of Progress and Strategies for the Future

24 April 2017 | Prague, Czech Republic

Laser Acceleration of Electrons, Protons, and Ions

13 April 2015 | Prague, Czech Republic

Showing 5 of 7 Conference Committees

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