Dr. Chris A. Campbell Profile

Dr. Chris A. Campbell

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Publications (6)

Proceedings Article | 13 March 2024 Presentation + Paper

Accurate burn wound categorization using an optimized spatial frequency domain imaging device and machine learning

Chris Campbell, Gordon Kennedy, Rebecca Rowland, Alexis Fox, Earl Steward, Theresa Chin, Victor Joe, Anthony Durkin

Proceedings Volume 12816, 1281604 (2024) https://doi.org/10.1117/12.3002918

KEYWORDS: Skin, Machine learning, Tissues, Spatial frequencies, Imaging devices

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Proceedings Article | 7 March 2023 Presentation + Paper

High-speed spatial parameter recovery using multi-distance frequency-domain diffuse optical spectroscopy

Robin Dale, Thomas O'Sullivan, Scott Howard, Chris Campbell, Felipe Orihuela-espina, Hamid Dehghani

Proceedings Volume 12376, 1237606 (2023) https://doi.org/10.1117/12.2651676

KEYWORDS: Tomography, Near infrared spectroscopy, Tissues, Signal attenuation, Optical properties, Tissue optics, Modulation frequency, Image resolution, Finite element methods, Scattering

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SPIE Journal Paper | 29 June 2021 Open Access

Broadband diffuse optical spectroscopy of absolute methemoglobin concentration can distinguish benign and malignant breast lesions

Sandhya Vasudevan, Chris Campbell, Fang Liu, Thomas O'Sullivan

JBO, Vol. 26, Issue 06, 065004, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.065004

KEYWORDS: Breast, Tissues, Collagen, Tissue optics, Diffuse optical spectroscopy, Absorption, Scattering, Breast cancer, Biopsy, Tumors

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Significance: Noninvasive diffuse optical spectroscopy (DOS) is a promising adjunct diagnostic imaging technique for distinguishing benign and malignant breast lesions. Most DOS approaches require normalizing lesion biomarkers to healthy tissue since major tissue constituents exhibit large interpatient variations. However, absolute optical biomarkers are desirable as it avoids reference measurements which may be difficult or impractical to acquire. Aim: Our goal is to determine whether absolute measurements of minor absorbers such as collagen and methemoglobin (metHb) can successfully distinguish lesions. We hypothesize that metHb would exhibit less interpatient variability and be more suitable as an absolute metric for malignancy. However, we would expect collagen to exhibit more variability, because unlike metHb, collagen is also present in the healthy tissue. Approach: In this retrospective clinical study, 30 lesions with breast imaging reporting and database system score ( BIRADS ) > = 3 (12 benign and 18 malignant) measured with broadband quantitative DOS were analyzed for their oxyhemoglobin (HbO), deoxyhemoglobin (HHb), water, lipids, collagen, metHb concentrations, and optical scattering characteristics. Wilcoxon rank sum test was used to compare benign and malignant lesions for all variables in both normalized and absolute forms. Results: Among all absolute DOS parameters considered, only absolute metHb was observed to be significant for lesion discrimination (0.43 ± 0.18 μM for benign versus 0.87 ± 0.32 μM for malignant, p = 0.0002). Absolute metHb concentration was also determined to be the best predictor of malignancy with an area under the curve of 0.89. Conclusions: Our findings demonstrate that lesion metHb concentration measured by DOS can improve noninvasive optical diagnosis of breast malignancies. Since metHb concentration found in normal breast tissue is extremely low, metHb may be a more direct indicator of malignancy that does not depend on other biomarkers found in healthy tissue with significant variability. Furthermore, absolute parameters require reduced measurement time and can be utilized in cases where healthy reference tissue is not available.

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