Fracture toughness, a bone’s resistance to breaking, is typically measured via invasive mechanical tests. In this ex vivo study on mouse femurs, four Raman spectral features associated with bone properties were significantly correlated to fracture toughness using a partial least squares regression model. By including parameters measured from dual-energy absorptiometry and micro-computed tomography in the model, fracture toughness predictions on ovariectomized mice were significantly lower than a control cohort’s. This shows that meaningful estimates of fracture toughness can be estimated using input parameters obtained non-destructively.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.