KEYWORDS: Algorithm development, Data storage, Data modeling, Detection and tracking algorithms, Computing systems, Machine learning, Data acquisition, Artificial intelligence
Any program tasked with the evaluation and acquisition of algorithms for use in deployed scenarios must have an impartial, repeatable, and auditable means of benchmarking both candidate and fielded algorithms. Success in this endeavor requires a body of representative sensor data, data labels indicating the proper algorithmic response to the data as adjudicated by subject matter experts, a means of executing algorithms under review against the data, and the ability to automatically score and report algorithm performance. Each of these capabilities should be constructed in support of program and mission goals. By curating and maintaining data, labels, tests, and scoring methodology, a program can understand and continually improve the relationship between benchmarked and fielded performance of acquired algorithms. A system supporting these program needs, deployed in an environment with sufficient computational power and necessary security controls is a powerful tool for ensuring due diligence in evaluation and acquisition of mission critical algorithms. This paper describes the Seascape system and its place in such a process.
Jennifer Barton, Photini Rice, Caitlin Howard, Jen Koevary, Forest Danford, David Gonzales, Jon Vande Geest, L. Daniel Latt, John Szivek, Richard Amodei, Michael Slayton
Tendinopathies and tendon tears heal slowly because tendons have a limited blood supply. Intense therapeutic ultrasound (ITU) is a treatment modality that creates very small, focal coagula in tissue, which can stimulate a healing response. This pilot study investigated the effects of ITU on rabbit and rat models of partial Achilles tendon rupture. The right Achilles tendons of 20 New Zealand White rabbits and 118 rats were partially transected. Twenty-four hours after surgery, ITU coagula were placed in the tendon and surrounding tissue, alternating right and left legs. At various time points, the following data were collected: ultrasound imaging, optical coherence tomography (OCT) imaging, mechanical testing, gene expression analysis, histology, and multiphoton microscopy (MPM) of sectioned tissue. Ultrasound visualized cuts and treatment lesions. OCT showed the effect of the interventions on birefringence banding caused by collagen organization. MPM showed inflammatory infiltrate, collagen synthesis and organization. By day 14- 28, all tendons had a smooth appearance and histology, MPM and OCT still could still visualize residual healing processes. Few significant results in gene expression were seen, but trends were that ITU treatment caused an initial decrease in growth and collagen gene expression followed by an increase. No difference in failure loads was found between control, cut, and ITU treatment groups, suggesting that sufficient healing had occurred by 14 days to restore all test tissue to control mechanical properties. These results suggest that ITU does not cause harm to tendon tissue. Upregulation of some genes suggests that ITU may increase healing response.
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