Current techniques trying to predict Alzheimer's disease at an early-stage explore the structural information of T1-weighted MR Images. Among these techniques, deep convolutional neural network (CNN) is the most promising since it has been successfully used in a variety of medical imaging problems. However, the majority of works on Alzheimer's Disease tackle the binary classification problem only, i.e., to distinguish Normal Controls from Alzheimer's Disease patients. Only a few works deal with the multiclass problem, namely, patient classification into one of the three groups: Normal Control (NC), Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI). In this paper, our primary goal is to tackle the 3-class AD classification problem using T1-weighted MRI and a 2D CNN approach. We used the first two layers of ResNet34 as feature extractor and then trained a classifier using 64 × 64 sized patches from coronal 2D MRI slices. Our extended-2D CNN proposal explores the MRI volumetric information, by using non-consecutive 2D slices as input channels of the CNN, while maintaining the low computational costs associated with a 2D approach. The proposed model, trained and tested on images from ADNI dataset, achieved an accuracy of 68.6% for the multiclass problem, presenting the best performance when compared to state-of-the-art AD classification methods, even the 3D-CNN based ones.
Corpus Callosum (CC) is the largest white matter structure and it plays a crucial role in clinical and research studies due to its shape and volume correlation to subject’s characteristics and neurodegenerative diseases. CC segmentation and parcellation are an important step for any MRI-based clinical and research study. There is only a few automatic CC parcellation methods proposed in the literature and, since it is not trivial to build a ground truth, most methods are validated qualitatively. We present a quantitative analysis of different state of art CC parcellation methods aiming to compare their results on a common dataset. Our findings show a significant difference among the same CC parcels, but using different CC parcellation methods, and its impact on the diffusion properties.
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