Fabrication via self-assembly has been explored for its potential to overcome the challenges of feature size/density and stochastic variability facing conventional lithographic approaches. While methods such as diblock-copolymer directed self-assembly have trouble meeting defectivity and edge-placement specifications, techniques such as atomic layer deposition and self-aligned sidewall-spacer methods are standard. Using DNA origami as an example, I will discuss the conditions for simple systems to form low-defectivity structures, and the potential for self-assembling systems to create complex, hierarchical nanostructures, and their inherent limitation. I will comment on choosing the right applications for the initial introduction of bottom-up fabrication methods.
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