A photonic crystal fiber (PCF)-based plasmonic biosensor for coronavirus detection is analyzed numerically. This can detect COVID spike protein, antibody and the viral ribonucleic acid (RNA) using multi-analyte sensing approach. It is optimized for the specific analytes’ refractive index (RI) range. The sensor shows the average wavelength sensitivities of 2,009 nm/RIU for the protein spike, 1984 nm/RIU for the antibody spike and 2745 nm/RIU for the mutant RNA spike, respectively. The corresponding amplitude sensitivities are 135 RIU-1, 140 RIU-1 and 196 RIU-1. We anticipate the proposed sensor to be a competitive candidate for rapid multi-analyte point-of-care COVID detection.
Dual microchannel (MCh) assist photonic crystal fiber-based plasmonic sensor has been proposed to detect a maximum of two analytes simultaneously. The proposed sensor will improve the detection time and accuracy. The performance of the sensor is investigated using the finite element method. Due to the symmetric structure, the proposed sensor shows similar performance for both channels. The sensor can be applied for both cases single and multi-analyte detection. The sensor exhibits the maximum wavelength sensitivity (WS) of 11,000 nm/RIU and amplitude sensitivity (AS) of 922 RIU-1for y-polarized modes, respectively. Due to the multi-analyte detection ability, the proposed sensor will be a suitable candidate for real-time biological and organic chemicals detections.
We propose a graphene embedded highly sensitive double D-shaped photonic crystal fiber (PCF) based plasmonic sensor for multi-analyte detection. The double D-shaped PCF is fabricated using the standard stack-and-draw method and utilizes the scanning electron microscope (SEM) image for numerical investigations. The double D-shape structure facilitates simultaneous multi-analyte detection capability. The proposed sensor exhibits the maximum wavelength and amplitude sensitivities of 14,000 nm/RIU and 1,922 RIU-1 for x-polarized mode respectively. Due to its highly sensitive response and multi-analyte detection capability, the proposed sensor will be a suitable candidate for medical diagnostics, biochemical, and organic chemical detection.
Development of label-free, highly sensitive, miniaturized surface plasmon resonance sensors enables real-time quantification of biomolecule interactions at atomic-levels, desirable for medical diagnostics and which will allow rapid clinical decisions. However, multi-target diagnostic assays require skilled labor, expensive materials, lengthy manual steps, as well as complicated analysis steps. Here, we develop a microfluidic-integrated digital optical disc (DVD) grating as a metasurface, which is coated with titanium-silver-gold (Ti-Ag-Au, 10, 30, and 15nm) for real-time monitoring of biomolecular interactions and binding affinities. Device fabrication process consists of poly (methyl methacrylate) (PMMA) microfluidic channel assembly on nanoplasmonic DVD surface gratings via double side adhesive (DSA) layers. Compared with other nano- and micro-fabrication methods, DVD-based sensor fabrication is relatively simple, cost-effective, and enables large-scale fabrication with minimum efforts. The plasmonic microfluidic chip surface was illuminated with a broadband light source and the normal reflection signal was monitored using a customized optical-setup. Maximum bulk sensitivity (337 nm/RIU) was observed with 30 seconds of etching period and low glycerol concentration (5%, v/v). Red-shifts of peak-wavelength (~16 nm) upon glycerol concentrations were observed as a function of time (seconds). A 0.6 nm peak-wavelength shift was observed in the step of EDC/NHS coupling and continuous protein A/G and G binding resulted in 0.353 ± 0.211 nm and 0.667 ± 0.116 nm (n=3, p<0.05). The presented platform could be potentially applicable to detect and real-time monitor of various biotargets including bacteria, cells, viruses, and proteins.
We propose a simple photonic crystal fiber (PCF) biosensor based on the surface plasmon resonance effect. The sensing properties are characterized using the finite element method. Chemically stable gold material is deposited on the outer surface of the PCF to realize the practical sensing approach. The performance of the modeled biosensor is investigated in terms of wavelength sensitivity, amplitude sensitivity, sensor resolution, and linearity of the resonant wavelength with the variation of structural parameters. In the sensing range of 1.33 to 1.37, maximum sensitivities of 4000 nm/RIU and 478 RIU−1 are achieved with the high sensor resolutions of 2.5×10−5 and 2.1×10−5 RIU using wavelength and amplitude interrogation methods, respectively. The designed biosensor will reduce fabrication complexity due to its simple and realistic hexagonal lattice structure. It is anticipated that the proposed biosensor may find possible applications for unknown biological and biochemical analyte detections with a high degree of accuracy.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.