Dr. Stephen Lam Profile

Dr. Stephen Lam

Professor of Medicine at BC Cancer Research Ctr

SPIE Involvement:

Author | Editor

Publications (39)

SPIE Journal Paper | 20 October 2020 Open Access

Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

Geoffrey Hohert, Renelle Myers, Sylvia Lam, Andrei Vertikov, Anthony Lee, Stephen Lam, Pierre Lane

JBO, Vol. 25, Issue 10, 106003, (October 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.10.106003

KEYWORDS: Biopsy, Optical coherence tomography, Tissues, Lung, In vivo imaging, Auto-fluorescence imaging, Diagnostics, Yield improvement, Visualization, Real time imaging

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Proceedings Article | 17 March 2020 Presentation

Machine learning and deep learning approaches for classification of sub-cm lung nodules in CT scans (Conference Presentation)

Rohan Abraham, Ian Janzen, Saeed Seyyedi, Sukhinder Khattra, John Mayo, Ren Yuan, Renelle Myers, Stephen Lam, Calum MacAulay

Proceedings Volume 11314, 113141G (2020) https://doi.org/10.1117/12.2546422

KEYWORDS: Machine learning, Lung, Computed tomography, Feature extraction, Lung cancer, Tissues, Scanners, Image classification

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Proceedings Article | 24 April 2018 Paper

Motion artifacts in endoscopic catheter-based images: simulation and motion correction method

Elham Abouei, Anthony M. D. Lee, Hamid Pahlevaninezhad, Geoffrey Hohert, Michelle Cua, Pierre Lane, Stephen Lam, Calum MacAulay

Proceedings Volume 10711, 107110E (2018) https://doi.org/10.1117/12.2317400

KEYWORDS: Motion models, Modeling and simulation, Nonuniformity corrections, Optical coherence tomography, In vivo imaging, Endoscopy, 3D image processing, Image registration, Imaging systems, Data acquisition

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Proceedings Article | 14 March 2018 Presentation

OCT for lung transplantation monitoring: quantification of chronic lung allograft dysfunction (CLAD) biomarkers (Conference Presentation)

Geoffrey Hohert, Anthony Lee, Sylvia Lam, Pierre Lane, Calum MacAulay, Stephen Lam, Roland Nador, Robert Levy, John English

Proceedings Volume 10470, 104700A (2018) https://doi.org/10.1117/12.2291389

KEYWORDS: Lung, Optical coherence tomography, Biopsy, Transplantation, Computed tomography, Diagnostics, Endoscopy, Surveillance, Bronchoscopy, 3D image processing

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SPIE Journal Paper | 4 January 2018 Open Access

Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration

Elham Abouei, Anthony M. D. Lee, Hamid Pahlevaninezhad, Geoffrey Hohert, Michelle Cua, Pierre Lane, Stephen Lam, Calum MacAulay

JBO, Vol. 23, Issue 01, 016004, (January 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.1.016004

KEYWORDS: Optical coherence tomography, In vivo imaging, 3D image processing, Endoscopy, Matrices, Visualization, Image registration, Atrial fibrillation, Tissues, Quantitative analysis

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Proceedings Article | 27 April 2016 Presentation

Correction of motion artifacts in OCT-AFI data collected in airways (Conference Presentation)

Elham Abouei, Pierre Lane, Hamid Pahlevaninezhad, Anthony Lee, Stephen Lam, Calum MacAulay

Proceedings Volume 9691, 96911H (2016) https://doi.org/10.1117/12.2213299

KEYWORDS: Optical coherence tomography, In vivo imaging, Medicine, Endoscopy, Image resolution, Tissue optics, Ophthalmology, Cardiology, Auto-fluorescence imaging, Tissues

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Proceedings Article | 27 April 2016 Presentation

In vivo imaging of pulmonary nodule and vasculature using endoscopic co-registered optical coherence tomography and autofluorescence imaging (Conference Presentation)

Hamid Pahlevaninezhad, Anthony Lee, Geoffrey Hohert, Carely Schwartz, Tawimas Shaipanich, Alexander Ritchie, Wei Zhang, Calum MacAulay, Stephen Lam, Pierre Lane

Proceedings Volume 9691, 96910Y (2016) https://doi.org/10.1117/12.2209686

KEYWORDS: Optical coherence tomography, Auto-fluorescence imaging, Visualization, Endoscopy, In vivo imaging, Lung, Biopsy, Fiber optics, Tissues, Collagen

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Proceedings Article | 26 April 2016 Presentation

Endoscopic high-resolution auto fluorescence imaging and optical coherence tomography of airways in vivo (Conference Presentation)

Hamid Pahlevaninezhad, Anthony Lee, Geoffrey Hohert, Carley Schwartz, Tawimas Shaipanich, Alexander Ritchie, Wei Zhang, Calum MacAulay, Stephen Lam, Pierre Lane

Proceedings Volume 9701, 97010D (2016) https://doi.org/10.1117/12.2209726

KEYWORDS: Optical coherence tomography, In vivo imaging, Endoscopy, Auto-fluorescence imaging, Coherence imaging, Imaging systems, Visualization, Lung, Luminescence, Optical imaging

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Proceedings Article | 2 March 2015 Paper

Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer

Wei Zhang, Alexander Ritchie, Hamid Pahlevaninezhad, Anthony Lee, Geoffrey Hohert, Lucas Cahill, Tawimas Shaipanich, Diana Ionescu, Calum MacAulay, Pierre Lane, Stephen Lam

Proceedings Volume 9304, 93040B (2015) https://doi.org/10.1117/12.2077848

KEYWORDS: Optical coherence tomography, Lung, Biopsy, Doppler tomography, Lung cancer, Blood vessels, Pathology, Atrial fibrillation, Bronchoscopy, Cancer

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SPIE Journal Paper | 31 March 2014 Open Access

Coregistered autofluorescence-optical coherence tomography imaging of human lung sections

Hamid Pahlevaninezhad, Anthony Lee, Stephen Lam, Calum MacAulay, Pierre Lane

JBO, Vol. 19, Issue 03, 036022, (March 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.3.036022

KEYWORDS: Atrial fibrillation, Optical coherence tomography, Tissues, Lung, Cartilage, Image segmentation, Connective tissue, Coherence imaging, Tissue optics, Scattering

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Proceedings Article | 4 March 2014 Paper

Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

Miranda Kirby, Anthony Lee, Tara Candido, Calum MacAulay, Pierre Lane, Stephen Lam, Harvey Coxson

Proceedings Volume 8927, 89271D (2014) https://doi.org/10.1117/12.2040866

KEYWORDS: Optical coherence tomography, Image segmentation, Image filtering, Cartilage, In vivo imaging, Lung, Computed tomography, Pulmonary disorders, Image acquisition, Nonlinear filtering

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Proceedings Article | 4 March 2014 Paper

Sex differences in chronic obstructive pulmonary disease evaluated using optical coherence tomography

Miranda Kirby, Wei Zhang, Peter Laratta, Don Sin, Stephen Lam, Harvey Coxson

Proceedings Volume 8927, 89270Z (2014) https://doi.org/10.1117/12.2040824

KEYWORDS: Optical coherence tomography, Chronic obstructive pulmonary disease, Lung, Pathophysiology, Spirometry, Adaptive optics, Image resolution, Computed tomography, Pathogens, Imaging systems

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SPIE Journal Paper | 9 October 2013 Open Access

Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

Hamid Pahlevaninezhad, Ivana Cecic, Anthony Lee, Alastair Kyle, Stephen Lam, Calum MacAulay, Pierre Lane

JBO, Vol. 18, Issue 10, 106007, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.106007

KEYWORDS: Atrial fibrillation, Optical coherence tomography, Tissues, Tissue optics, Scattering, Signal attenuation, 3D modeling, Absorption, Luminescence, 3D image processing

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SPIE Journal Paper | 25 April 2013 Open Access

In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

Anthony M. Lee, Keishi Ohtani, Calum MacAulay, Annette McWilliams, Tawimas Shaipanich, Victor X. Yang, Stephen Lam, Pierre Lane

JBO, Vol. 18, Issue 05, 050501, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.050501

KEYWORDS: Optical coherence tomography, Lung, Fiber optics, Doppler tomography, In vivo imaging, Visualization, Doppler effect, Video, 3D visualizations, 3D image processing

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Proceedings Article | 8 March 2013 Paper

OCT imaging in chronic obstructive pulmonary disease

K. Ohtani, R. Lopez Lisbona, A. M. Lee, C. Hyun, T. Shaipanich, A. McWilliams, P. Lane, H. Coxson, C. MacAulay, S. Lam

Proceedings Volume 8565, 85652T (2013) https://doi.org/10.1117/12.2005206

KEYWORDS: Optical coherence tomography, Chronic obstructive pulmonary disease, Computed tomography, Lung, 3D image processing, Image segmentation, Americium, Cancer, In vivo imaging, Image resolution

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Proceedings Article | 8 March 2013 Paper

Correction of autofluorescence intensity for epithelial scattering by optical coherence tomography: a phantom study

H. Pahlevaninezhad, A. M. Lee, C. Hyun, S. Lam, C. MacAulay, P. Lane

Proceedings Volume 8565, 85652S (2013) https://doi.org/10.1117/12.2004531

KEYWORDS: Atrial fibrillation, Scattering, Optical coherence tomography, Signal attenuation, Light scattering, Tissues, Tissue optics, Imaging systems, Geometrical optics, Sensors

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Proceedings Article | 18 February 2012 Paper

Lung vasculature imaging using speckle variance optical coherence tomography

Michelle Cua, Anthony M. Lee, Pierre Lane, Annette McWilliams, Tawimas Shaipanich, Calum MacAulay, Victor X. Yang, Stephen Lam

Proceedings Volume 8207, 82073P (2012) https://doi.org/10.1117/12.906903

KEYWORDS: Optical coherence tomography, Lung, Speckle, Lung cancer, Chronic obstructive pulmonary disease, In vivo imaging, Endoscopy, Signal detection, Speckle imaging, Coherence imaging

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Proceedings Article | 9 February 2012 Paper

Improvements to a laser Raman spectroscopy system for reducing the false positives of autofluorescence bronchoscopies

Hanna Pawluk, Michael Short, Stephen Lam, Annette McWilliams, Diana Ionescue, Haishan Zeng

Proceedings Volume 8207, 820737 (2012) https://doi.org/10.1117/12.908739

KEYWORDS: Raman spectroscopy, Bronchoscopy, Charge-coupled devices, Tissues, Signal to noise ratio, Laser spectroscopy, Cancer, In vivo imaging, Spectrographs, Systems modeling

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Proceedings Article | 9 March 2011 Paper

Automated segmentation of lung airway wall area measurements from bronchoscopic optical coherence tomography imaging

Mohammadreza Heydarian, Stephen Choy, Andrew Wheatley, David McCormack, Harvey Coxson, Stephen Lam, Grace Parraga

Proceedings Volume 7965, 79651M (2011) https://doi.org/10.1117/12.878194

KEYWORDS: Optical coherence tomography, Image segmentation, Lung, Chronic obstructive pulmonary disease, Fuzzy logic, Coherence imaging, Spatial resolution, RGB color model, X-ray computed tomography, Optical imaging

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SPIE Journal Paper | 1 March 2009 Open Access

Confocal fluorescence microendoscopy of bronchial epithelium

Pierre Lane, Stephen Lam, Annette McWilliams, Jean Le Riche, Marshall Anderson, Calum MacAulay

JBO, Vol. 14, Issue 02, 024008, (March 2009) https://doi.org/10.1117/12.10.1117/1.3103583

KEYWORDS: Confocal microscopy, Luminescence, Biopsy, Objectives, Tissues, In vivo imaging, Cancer, Microscopes, Lung cancer, Optical filters

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Proceedings Article | 29 February 2008 Paper

Automated tissue m-FISH analysis workstation for identification of clonally related cells

Piotr Dubrowski, Wan Lam, Victor Ling, Stephen Lam, Calum MacAulay

Proceedings Volume 6859, 68591T (2008) https://doi.org/10.1117/12.763519

KEYWORDS: Image segmentation, Tissues, Computer generated holography, Genetics, Cancer, Lung cancer, Image processing algorithms and systems, Luminescence, Image acquisition, Resistance

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Proceedings Article | 8 February 2008 Paper

Development and preliminary results of an in vivo Raman probe for early lung cancer detection

Michael Short, Stephen Lam, Annette McWilliams, Jianhua Zhao, Harvey Lui, Haishan Zeng

Proceedings Volume 6853, 68530J (2008) https://doi.org/10.1117/12.764034

KEYWORDS: Raman spectroscopy, Lung cancer, In vivo imaging, Tissue optics, Spectroscopy, Lung, Optical filters, Charge-coupled devices, Cancer, Tissues

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Proceedings Article | 18 January 2005 Paper

Near-infrared Raman spectroscopy detects lung cancer

Zhiwei Huang, Harvey Lui, Annette McWilliams, Stephen Lam, David McLean, Haishan Zeng

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.577419

KEYWORDS: Tissues, Raman spectroscopy, Tumors, Lung cancer, Tissue optics, Near infrared, Proteins, Cancer, Diagnostics, Luminescence

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Proceedings Article | 27 April 2000 Paper

Quantitative architectural analysis of bronchial intraepithelial neoplasia

Martial Guillaud, Calum MacAulay, Jean Le Riche, Chris Dawe, Jagoda Korbelik, Stephen Lam

Proceedings Volume 3921, (2000) https://doi.org/10.1117/12.384231

KEYWORDS: Biopsy, Pathology, Tissues, Biological research, Cancer, Lung cancer, Statistical analysis, Lung, Feature extraction, Visualization

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Proceedings Article | 17 September 1999 Paper

Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection

Haishan Zeng, Calum MacAulay, Stephen Lam, Branko Palcic

Proceedings Volume 3863, (1999) https://doi.org/10.1117/12.364398

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Proceedings Article | 29 April 1998 Paper

Intermediate endpoint biomarkers for lung cancer chemoprevention

Calum MacAulay, Stephen Lam, Helga Klein-Parker, Adi Gazdar, Martial Guillaud, Peter Payne, Jean Le Riche, Chris Dawe, Pierre Band, Branko Palcic

Proceedings Volume 3260, (1998) https://doi.org/10.1117/12.307094

KEYWORDS: Biopsy, Lung cancer, Cancer, Tissues, Genetics, Luminescence, Visualization, Proteins, Cervical cancer, Endoscopy

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SPIE Journal Paper | 1 November 1995

Laser-induced fluorescence spectroscopy at endoscopy: tissue optics, Monte Carlo modeling, and in vivo measurements

Jianan Qu, Calum MacAulay, Stephen Lam, Branko Palcic

OE, Vol. 34, Issue 11, (November 1995) https://doi.org/10.1117/12.10.1117/12.212917

KEYWORDS: Luminescence, Tissues, Blood, In vivo imaging, Tissue optics, Laser induced fluorescence, Monte Carlo methods, Absorption, Optical properties, In vitro testing

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Proceedings Article | 12 May 1995 Paper

Optical properties of normal and malignant tissues in the nasopharynx and larynx

Calum MacAulay, Stephen Lam, Jianan Qu, C. Man, M. Harries, Branko Palcic

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209097

KEYWORDS: Tissues, Lung, Optical properties, Copper indium disulfide, Cancer, Fiber optics, Absorption, In vivo imaging, Biopsy, Luminescence

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Proceedings Article | 12 April 1995 Paper

Mechanisms of ratio fluorescence imaging of diseased tissue

Jianan Qu, Calum MacAulay, Stephen Lam, Branko Palcic

Proceedings Volume 2387, (1995) https://doi.org/10.1117/12.206806

KEYWORDS: Luminescence, Tissues, Tissue optics, Tumor growth modeling, Monte Carlo methods, Blood, In vivo imaging, Copper indium disulfide, Optical properties, Laser tissue interaction

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Proceedings Article | 4 January 1995 Paper

Fluorescence imaging of early lung cancer

Stephen Lam, Calum MacAulay, Jean Le Riche, Norihiko Ikeda, Branko Palcic

Proceedings Volume 2324, (1995) https://doi.org/10.1117/12.198716

KEYWORDS: Luminescence, Lung, Bronchoscopy, Tissues, Tissue optics, Lung cancer, Copper indium disulfide, Fluorescence spectroscopy, Image processing, Cancer

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Proceedings Article | 17 August 1994 Paper

Fluorescence in normal and carcinoma bronchial tissue

Jianan Qu, Calum MacAulay, Stephen Lam, Haishan Zeng, Branko Palcic

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182938

KEYWORDS: Tissues, Luminescence, Monte Carlo methods, Optical properties, Optical spectroscopy, Absorption, Light scattering, Scattering, Anisotropy, Collimation

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Proceedings Article | 19 July 1994 Paper

Laser-induced fluorescence spectroscopy at endoscopy

Jianan Qu, Calum MacAulay, Stephen Lam, Branko Palcic

Proceedings Volume 2133, (1994) https://doi.org/10.1117/12.179979

KEYWORDS: Tissues, Luminescence, Cancer, Monte Carlo methods, Laser induced fluorescence, Spectroscopy, Endoscopy, Fluorescence spectroscopy, Tumors, In vivo imaging

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Proceedings Article | 18 June 1993 Paper

Fluorescence imaging of premalignant and malignant tissues with and without photosensitizers

Stephen Lam, Calum MacAulay, Jean Le Riche, Jianan Qu, Gorazd Krosl, Haishan Zeng, Mladen Korbelik, Branko Palcic

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146306

KEYWORDS: Luminescence, Lung cancer, Tissues, Tumors, Cancer, Bronchoscopy, Helium cadmium lasers, Tumor growth modeling, Imaging devices, CCD cameras

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Proceedings Article | 5 March 1993 Paper

Combined photodynamic therapy using Photofrin and radiotherapy versus radiotherapy alone in patients with inoperable obstructive nonsmall-cell bronchogenic carcinoma

Stephen Lam, C. Grafton, P. Coy, N. Voss, R. Fairey

Proceedings Volume 1616, (1993) https://doi.org/10.1117/12.137038

KEYWORDS: Photodynamic therapy, Tumors, Radiotherapy, Bronchoscopy, Computed tomography, Blood, Skin, Chest imaging, Safety, Lung

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Proceedings Article | 5 March 1993 Paper

Detection of oral squamous-cell cancer and precancerous lesions by fluorescence imaging in a hamster cheek-pouch model

Stephen Lam, A. Kluftinger, J. Hung, N. Davis, N. Quenville, Branko Palcic

Proceedings Volume 1616, (1993) https://doi.org/10.1117/12.136979

KEYWORDS: Luminescence, Cancer, Tumor growth modeling, Tissues, Animal model studies, Silicon, Helium cadmium lasers, Video, Tumors, Biopsy

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Proceedings Article | 1 June 1991 Paper

Microlocalization of Photofrin in neoplastic lesions

Mladen Korbelik, Gorazd Krosl, Stephen Lam, David Chaplin, Branko Palcic

Proceedings Volume 1426, (1991) https://doi.org/10.1117/12.44056

KEYWORDS: Tumors, Luminescence, Lung, Blood vessels, Fluorescence spectroscopy, Photodynamic therapy, Tissues, Tumor growth modeling, Imaging systems, Animal model studies

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Proceedings Article | 1 June 1991 Paper

Endoscopic fluorescence detection of early lung cancer

A. Profio, Oscar Balchum, Stephen Lam

Proceedings Volume 1426, (1991) https://doi.org/10.1117/12.44047

KEYWORDS: Luminescence, Tumors, Waveguides, Lung cancer, Tissue optics, Optical filters, Fluorescence spectroscopy, Fluorometers, Fiber optics, Endoscopy

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Proceedings Article | 1 June 1991 Paper

Lung imaging fluorescence endoscope: development and experimental prototype

Branko Palcic, Stephen Lam, Calum MacAulay, Jaclyn Hung, Bruno Jaggi, Massud Radjinia, Alfred Pon, A. Profio

Proceedings Volume 1448, (1991) https://doi.org/10.1117/12.45350

KEYWORDS: Lung cancer, Luminescence, Imaging systems, Tumors, Cancer, Tissues, Endoscopes, Lung imaging, Prototyping, Sensors

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Proceedings Article | 1 July 1990 Paper

Detection of lung cancer by ratio fluorometry with and without Photofrin II

Stephen Lam, Jaclyn Hung, Branko Palcic

Proceedings Volume 1201, (1990) https://doi.org/10.1117/12.17585

KEYWORDS: Luminescence, Tumors, Lung cancer, Skin, Tissues, Cancer, Biopsy, Bronchoscopy, Medicine, Fluorometers

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Showing 5 of 39 publications

Proceedings Volume Editor (5)

SPIE Conference Volume | 26 May 2016

Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III

SPIE Conference Volume | 24 March 2015

Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II

SPIE Conference Volume | 18 March 2014

Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine

SPIE Conference Volume | 15 March 2013

Photonic Therapeutics and Diagnostics IX

SPIE Conference Volume | 3 February 2012

Photonic Therapeutics and Diagnostics VIII

Conference Committee Involvement (24)

Endoscopic Microscopy XVIII

28 January 2023 | San Francisco, California, United States

Endoscopic Microscopy XVII

22 January 2022 | San Francisco, California, United States

Endoscopic Microscopy XVI

6 March 2021 | Online Only, California, United States

Endoscopic Microscopy XV

1 February 2020 | San Francisco, California, United States

Endoscopic Microscopy XIV

2 February 2019 | San Francisco, California, United States

Endoscopic Microscopy XIII

27 January 2018 | San Francisco, California, United States

Endoscopic Microscopy XII

29 January 2017 | San Francisco, California, United States

Optical Techniques in Pulmonary Medicine IV

28 January 2017 | San Francisco, California, United States

Endoscopic Microscopy XI

14 February 2016 | San Francisco, California, United States

Optical Techniques in Pulmonary Medicine III

13 February 2016 | San Francisco, California, United States

Endoscopic Microscopy X

8 February 2015 | San Francisco, California, United States

Optical Techniques in Pulmonary Medicine II

7 February 2015 | San Francisco, California, United States

Endoscopic Microscopy IX

2 February 2014 | San Francisco, California, United States

Optical Techniques in Pulmonary Medicine

1 February 2014 | San Francisco, California, United States

Endoscopic Microscopy VIII

3 February 2013 | San Francisco, California, United States

Optical Techniques in Pulmonary Medicine

2 February 2013 | San Francisco, California, United States

Endoscopic Microscopy VII

22 January 2012 | San Francisco, California, United States

Optical Techniques in Pulmonary Medicine

21 January 2012 | San Francisco, California, United States

Endoscopic Microscopy VI

23 January 2011 | San Francisco, California, United States

Endoscopic Microscopy V

25 January 2010 | San Francisco, California, United States

Endoscopic Microscopy IV

25 January 2009 | San Jose, California, United States

Endoscopic Microscopy III

20 January 2008 | San Jose, California, United States

Endoscopic Microscopy II

21 January 2007 | San Jose, California, United States

Endoscopic Microscopy

22 January 2006 | San Jose, California, United States

Showing 5 of 24 Conference Committees

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