Dr. Xuxin Chen Profile

Dr. Xuxin Chen

Postdoctoral Fellow

SPIE Involvement:

Author

Publications (12)

Proceedings Article | 3 April 2024 Presentation + Paper

David vs. Goliath: large foundation models are not outperforming small models in multi-view mammogram breast cancer prediction

Xuxin Chen, Mingzhe Hu, Ke Zhang, Neman Abdoli, Youkabed Sadri, Patrik Gilley, Omkar Saiswaroop Varma Chekuri, Farid Omoumi, Yuchen Qiu, Bin Zheng, Xiaofeng Yang

Proceedings Volume 12927, 129270X (2024) https://doi.org/10.1117/12.3007054

KEYWORDS: Mammography, Transformers, Breast cancer, Medical image processing, Deep learning, Computer aided detection

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Proceedings Article | 12 March 2024 Paper

Evaluating the imaging quality of multiplexed illumination Fourier ptychography microscopy

Patrik Gilley, Ke Zhang, Neman Abdoli, Youkabed Sadri, Xuxin Chen, Kar-Ming Fung, Hong Liu, Yuchen Qiu

Proceedings Volume 12843, 1284306 (2024) https://doi.org/10.1117/12.3001674

KEYWORDS: Light emitting diodes, Multiplexing, Image quality, Image processing, Medical image reconstruction

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Proceedings Article | 12 March 2024 Poster + Paper

Assessing detectability improvement of a self-supervised noise reduction algorithm for phase-sensitive breast tomosynthesis phantom images

Jared Nelson, Xuxin Chen, Yuhua Li, Farid Omoumi, Molly Donovan Wong, Hong Liu

Proceedings Volume 12843, 1284309 (2024) https://doi.org/10.1117/12.3004490

KEYWORDS: Denoising, Aluminum, Image processing, Breast, Tomosynthesis, X-rays, Image quality, Education and training, X-ray imaging, Mammography

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Proceedings Article | 10 April 2023 Presentation + Paper

Quantitative methods for molecular ultrasound imaging

Negar Sadeghipour, Farbod Tabesh, Arutselvan Natarajan, Meredith Jones, Xuxin Chen, Ramasamy Paulmurugan, Bin Zheng, Ahmed El Kaffas

Proceedings Volume 12470, 124700F (2023) https://doi.org/10.1117/12.2654230

KEYWORDS: Ultrasonography, Tumors, Cancer, Biological imaging, Proteins, Bubbles, Blood vessels, Image enhancement

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Proceedings Article | 14 March 2023 Poster + Paper

The impact of external filtration on image quality and exposure time of an in-line phase-contrast x-ray breast imaging prototype

Farid Omoumi, Xuxin Chen, Yuchen Qiu, Yuhua Li, Bin Zheng, Hong Liu

Proceedings Volume 12380, 123800L (2023) https://doi.org/10.1117/12.2649343

KEYWORDS: X-ray imaging, Image quality, Breast imaging

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Proceedings Article | 14 March 2023 Paper

Comparing the effectiveness of 2D and 3D features on predicting the response to chemotherapy for ovarian cancer patients

Neman Abdoli, Patrik Gilley, Ke Zhang, Xuxin Chen, Theresa Thai, Kathleen Moore, Robert Mannel, Yuchen Qiu

Proceedings Volume 12380, 123800D (2023) https://doi.org/10.1117/12.2655153

KEYWORDS: Radiomics, Ovarian cancer, Computed tomography

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Proceedings Article | 2 March 2022 Paper

Improving the resolution of chromosome imaging by high numerical aperture Fourier ptychography microscopy

Ke Zhang, Patrik Gilley, Xianglan Lu, Xuxin Chen, Neman Abdoli, Roy Zhang, Kar-Ming Fung, Hong Liu, Bin Zheng, Shibo Li, Yuchen Qiu

Proceedings Volume 11961, 1196102 (2022) https://doi.org/10.1117/12.2610806

KEYWORDS: Microscopy

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Proceedings Article | 2 March 2022 Poster + Paper

Virtual adversarial training for semi-supervised breast mass classification

Xuxin Chen, Ximin Wang, Ke Zhang, Kar-Ming Fung, Theresa Thai, Kathleen Moore, Robert Mannel, Hong Liu, Bin Zheng, Yuchen Qiu

Proceedings Volume 11961, 1196106 (2022) https://doi.org/10.1117/12.2611851

KEYWORDS: Medical imaging, Mammography, Cancer

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SPIE Journal Paper | 31 January 2022 Open Access

Using Fourier ptychography microscopy to achieve high-resolution chromosome imaging: an initial evaluation

Ke Zhang, Xianglan Lu, Xuxin Chen, Roy Zhang, Kar-Ming Fung, Hong Liu, Bin Zheng, Shibo Li, Yuchen Qiu

JBO, Vol. 27, Issue 01, 016504, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.016504

KEYWORDS: Objectives, Modulation transfer functions, Microscopes, Microscopy, Lenses, Imaging systems, Leukemia, Blood, Spectral resolution, Statistical analysis

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Significance: Searching analyzable metaphase chromosomes is a critical step for the diagnosis and treatment of leukemia patients, and the searching efficiency is limited by the difficulty that the conventional microscopic systems have in simultaneously achieving high resolution and a large field of view (FOV). However, this challenge can be addressed by Fourier ptychography microscopy (FPM) technology. Aim: The purpose of this study is to investigate the feasibility of utilizing FPM to reconstruct high-resolution chromosome images. Approach: An experimental FPM prototype, which was equipped with 4 × / 0.1 NA or 10 × / 0.25 NA objective lenses to achieve a theoretical equivalent NA of 0.48 and 0.63, respectively, was developed. Under these configurations, we first generated the system modulation transfer function (MTF) curves to assess the resolving power. Next, a group of analyzable metaphase chromosomes were imaged by the FPM system, which were acquired from the peripheral blood samples of the leukemia patients. The chromosome feature qualities were evaluated and compared with the results accomplished by the corresponding conventional microscopes. Results: The MTF curve results indicate that the resolving power of the 4 × / 0.1 NA FPM system is equivalent and comparable to the 20 × / 0.4 NA conventional microscope, whereas the performance of the 10 × / 0.25 NA FPM system is close to the 60 × / 0.95 NA conventional microscope. When imaging the chromosomes, the feature qualities of the 4 × / 0.1 NA FPM system are comparable to the results under the conventional 20 × / 0.4 NA lens, whereas the feature qualities of the 10 × / 0.25 NA FPM system are better than the conventional 60 × / 0.95 NA lens and comparable to the conventional 100 × / 1.25 NA lens. Conclusions: This study initially verified that it is feasible to utilize FPM to develop a high-resolution and wide-field chromosome sample scanner.

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