Mr. Yuli Li Profile

Yuli Li

at Nanchang Univ

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Publications (3)

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Proceedings Article | 18 June 2021 Paper

Optical and thermal interactions of different-wavelength ultrashort laser pulses with breast cancer based on COMSOL

Yuli Li, Ao Teng, Zihao Li, Xianlin Song

Proceedings Volume 11850, 1185007 (2021) https://doi.org/10.1117/12.2599023

Read Abstract +

We use commercial finite element simulation software COMSOL Multiphysics to simulate the generation and propagation of photothermal signals. The software is based on the finite element method, solving actual physical phenomena, through mathematical methods to solve partial differential equations to simulate real physical phenomena. Its advantages mainly include excellent computing performance and multi-field coupling ability, accurate numerical simulation results, and good calculation for various physical phenomena in various fields of scientific research. In the visualization research of breast cancer photothermal imaging in this paper. We mainly simulate the generation and transmission of breast cancer photothermal effect through two modules: light transmission module and biological heat transfer module. We use the simulation software COMSOL Multiphysics to develop a computer numerical simulation model composed of water, tumor, breast tissue, subcutaneous tissue, epithelial tissue and short pulse laser sources of different wavelengths. The model studied the propagation and heat transfer of laser at 633nm, 700nm, 752nm and 900nm in the human breast. The energy transfer from the water layer to the breast tissue is described by the diffusion equation or the Helmholtz equation. The temperature change of the breast tumor and each breast tissue is obtained by solving the biological heat transfer equation. The interaction of the short pulse laser with the breast model at different wavelengths was obtained.

Proceedings Article | 5 March 2021 Presentation + Paper

Analysis on the photonic transmission and heat transfer of pulsed laser and breast cancer based on COMSOL multiphysics

Xianlin Song, Yuli Li, Ao Teng, Bo Li, Qiming He, Jinhong Zhang, Aojie Zhao, Zihao Li, Hao Chen, Jianshuang Wei, Lingfang Song, Cong Liu

Proceedings Volume 11622, 116220N (2021) https://doi.org/10.1117/12.2589051

KEYWORDS: Breast, Breast cancer, Tumors, Tumor growth modeling, Photoacoustic imaging, Mammary gland, Laser tissue interaction, Tissues, Oncology, Cancer

Read Abstract +

Human female breast is composed of skin, fibrous tissue, breast glands and fat. Breast cancer is a malignant tumor that occurs in the epithelial tissue of breast glands. The breast is not an important organ for maintaining human life. Breast cancer in situ is not fatal; however, because breast cancer cells lose the characteristics of normal cells, the connections between cells are loose and easy to fall off. Once the cancer cells fall off, the free cancer cells can spread throughout the body with the blood or lymph fluid, forming metastases, and endangering life. Breast cancer has become a common tumor threatening women's physical and mental health. Therefore, studying the interaction between laser and breast tissue and breast tumors has important theoretical and practical significance for the treatment of breast cancer. To this end, this research uses the commercial finite element simulation software COMSOL Multiphysics to develop a two-dimensional numerical simulation model based on finite element, which studies the propagation and heat transfer of light in the breast of breast cancer patients. In this study, the model consists of four parts: 1) water layer; 2) breast; 3) breast tumor; 4) short pulse laser source (wavelength is 840nm). The laser point source is located in the middle of the water layer above the breast tissue to irradiate the breast and tumor. Simulate the propagation of light in the breast and tumor by solving the diffusion equation. The temperature changes of breast tissue and breast tumors are obtained by solving the biological heat transfer equation. This research helps to understand the spread of light in human breasts and breast tumors and the interaction between the two, and has certain theoretical guiding significance for the research and treatment of breast cancer.

Proceedings Article | 28 February 2021 Paper

Construction of breast cancer photoacoustic imaging model based on COMSOL

Xianlin Song, Yuli Li, Ao Teng, Zhipeng Zhang, Qiming He, Jinhong Zhang, Aojie Zhao, Bo Li, Zihao Li, Jianshuang Wei, Lingfang Song

Proceedings Volume 11781, 117810P (2021) https://doi.org/10.1117/12.2591388

Read Abstract +

Human female mammary gland is by skin, fibrous tissue, mammary gland and adipose composition, breast cancer is the malignant tumor that occurs in mammary gland epithelial tissue. Mammary gland is not an important organ to maintain human life activities. Breast cancer in situ is not fatal. However, due to the loss of the characteristics of normal cells, the cells are loosely connected and easy to fall off. Once cancer cells are shed, free cancer cells can spread throughout the body with blood or lymph, forming metastases and endangering life. At present, breast cancer has become a common tumor threatening women's physical and mental health. Therefore, studying the interaction of laser with breast tissue and breast tumor has important theoretical and practical significance for the treatment of breast cancer. For this reason, this study developed a two-dimensional numerical simulation model based on finite element using COMSOL Multiphysics, a commercial finite element simulation software, which studied the transmission and heat transfer of light in breast cancer patients. In this study, the model consists of four parts: 1) Water layer; 2) Breast; 3) Breast tumor; 4) short pulse laser source (wavelength: 840nm). The laser point source is located in the middle of the water layer above the breast tissue to irradiate the breast and the tumor. The propagation of light in breast and tumor was simulated by solving the diffusion equation. The temperature changes of breast tissue and breast tumor were obtained by solving the biological heat transfer equation. This study is helpful to understand the transmission of light in human breast and breast tumor as well as the interaction between the two, and has certain theoretical guiding significance for the research and treatment of breast cancer.

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