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13 March 2024 investigation of skin dynamic response after precise multiphoton photothermolysis using noninvasive multimodality microscopy and imaging-guided micro-Raman spectroscopy
Shujian Li, Yunxian Tian, Zhenguo Wu, Jianhua Zhao, Harvey Lui, Sunil Kalia, Haishan Zeng
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Proceedings Volume PC12816, Photonics in Dermatology and Plastic Surgery 2024; PC1281605 (2024) https://doi.org/10.1117/12.3008995
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The key objective of this study is to test the ability of a newly developed laser therapy technique – multiphoton photothermolysis – to generate precise tissue alteration on in vivo human skin, and to demonstrate the efficiency of a prototype multimodal microscopy to monitor skin response in real-time after the laser treatment. Cellular activities such as proliferation, inflammation, exfoliation of injured tissue can be captured over time. This study highlights the potential use of multiphoton photothermolysis for treatment of conditions that preventing collateral damage is critical. Also, multimodal microscopy offers a non-invasive method for monitoring tissue physiology.
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Shujian Li, Yunxian Tian, Zhenguo Wu, Jianhua Zhao, Harvey Lui, Sunil Kalia, and Haishan Zeng "investigation of skin dynamic response after precise multiphoton photothermolysis using noninvasive multimodality microscopy and imaging-guided micro-Raman spectroscopy", Proc. SPIE PC12816, Photonics in Dermatology and Plastic Surgery 2024, PC1281605 (13 March 2024); https://doi.org/10.1117/12.3008995
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KEYWORDS
Skin
Micro raman spectroscopy
Multiphoton microscopy
Spectral response
Imaging systems
Multimodal imaging
Tissues
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