Deep cutaneous hypervascularization treatment using combined laser and ultrasound

Mingyang Wang; Yannis M. Paulus; Xinmai Yang; Xueding Wang

doi:10.1117/12.3000986

13 March 2024 Deep cutaneous hypervascularization treatment using combined laser and ultrasound

Mingyang Wang, Yannis M. Paulus, Xinmai Yang, Xueding Wang

Author Affiliations +

Proceedings Volume PC12816, Photonics in Dermatology and Plastic Surgery 2024; PC128160C (2024) https://doi.org/10.1117/12.3000986
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We have recently developed a novel, cavitation-based, highly selective anti-vascular technique, termed photo-mediated ultrasound therapy (PUT). In this study, the effectiveness and safety of PUT on cutaneous vascular malformation was examined through in vivo experiments in a clinically relevant chicken wattle model. The typical results showed perfusion stop of microvessel on OCT angiography and fade of the wattle color on skin imager after treatment. The safety is checked by H&E histology and immunohistochemistry evaluations include: CD31, Caspase-3, and Masson’s Trichrome (MTC) stains. The findings demonstrate that PUT can efficiently and safely remove hypervascular dermal capillaries by using laser fluence at a level which is orders of magnitude smaller than that used in conventional laser treatment of vascular lesions, thus offering a safer alternative technique for clinical management of cutaneous vascular malformations.

Conference Presentation

Citation Download Citation

Mingyang Wang, Yannis M. Paulus, Xinmai Yang, and Xueding Wang "Deep cutaneous hypervascularization treatment using combined laser and ultrasound", Proc. SPIE PC12816, Photonics in Dermatology and Plastic Surgery 2024, PC128160C (13 March 2024); https://doi.org/10.1117/12.3000986

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