Label-free visualization of far UV-C skin safety with dynamic optical coherence tomography with microscopic resolution (dmOCT)

Felix Hilge; Michael Wang-Evers; Lara Buhl; Heather Downs; Maron Dolling; Gereon Hüttmann; Reginald Birngruber; Dieter Manstein

doi:10.1117/12.3005568

13 March 2024 Label-free visualization of far UV-C skin safety with dynamic optical coherence tomography with microscopic resolution (dmOCT)

Felix Hilge, Michael Wang-Evers, Lara Buhl, Heather Downs, Maron Dolling, Gereon Hüttmann, Reginald Birngruber, Dieter Manstein

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Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128302M (2024) https://doi.org/10.1117/12.3005568
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The COVID-19 pandemic increased interest in large-scale disinfection of public spaces using UV-C germicidal lights. However, excessive UV-C exposure harms the skin and cornea. Although novel Far UV-C (180 – 230 nm) sources are widely considered safe, an easy and non-invasive experimental assessment of UV damage could help to exclude any health risks of extensive Far UV-C exposure. Dynamic-microscopic optical coherence tomography (dmOCT) is a non-invasive, label-free technique providing sub-cellular resolution images. This study used dmOCT to confirm Far UV-C's skin safety with in-vitro models. Results showed no signs of keratinocyte damage, while UV-B exposed samples express immediate structural and functional changes.

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Felix Hilge, Michael Wang-Evers, Lara Buhl, Heather Downs, Maron Dolling, Gereon Hüttmann, Reginald Birngruber, and Dieter Manstein "Label-free visualization of far UV-C skin safety with dynamic optical coherence tomography with microscopic resolution (dmOCT)", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128302M (13 March 2024); https://doi.org/10.1117/12.3005568

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KEYWORDS

Skin

Optical coherence tomography

Safety

Ultraviolet radiation

Visualization

Biological imaging

Tissues

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