The COVID-19 pandemic increased interest in large-scale disinfection of public spaces using UV-C germicidal lights. However, excessive UV-C exposure harms the skin and cornea. Although novel Far UV-C (180 – 230 nm) sources are widely considered safe, an easy and non-invasive experimental assessment of UV damage could help to exclude any health risks of extensive Far UV-C exposure.
Dynamic-microscopic optical coherence tomography (dmOCT) is a non-invasive, label-free technique providing sub-cellular resolution images. This study used dmOCT to confirm Far UV-C's skin safety with in-vitro models. Results showed no signs of keratinocyte damage, while UV-B exposed samples express immediate structural and functional changes.
Large area fractional laser treatment (LAFLT) is a new fat removal and weight loss concept, which applies microscopic thermal injuries to large parts of the skin. These injuries induce a controlled metabolic response which temporarily increases the energy expenditure (EE), thereby reducing overall weight. In a mouse model, we investigated the dosimetry settings to induce this metabolic reaction. Therefore, mice were housed in metabolic cages and their body composition was analyzed. Results showed a significant EE increase (31% - 91%, p < 0.05) over a 6-day period which seems to suggest that an enhanced metabolic state can be achieved.
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