Fabrication of nanoresonator biosensing arrays using nanoimprint lithography

Alex Janzen; Sommayyeh Poshtiban; Amit Singh; Stephane Evoy

doi:10.1117/1.JMM.11.2.023013

20 June 2012 Fabrication of nanoresonator biosensing arrays using nanoimprint lithography

Alex Janzen, Sommayyeh Poshtiban, Amit Singh, Stephane Evoy

Journal of Micro/Nanolithography, MEMS, and MOEMS, Vol. 11, Issue 2, 023013 (June 2012). https://doi.org/10.1117/1.JMM.11.2.023013

Abstract

Nanoimprint lithography was used to fabricate arrays of SiCN nanoscale resonators for biological analysis applications. A bilayer resist consisting of PMMA 495/LOR 3A allowed high fabrication yields for resonators of widths ranging from 120 to 300 nm, thicknesses of 40 and 70 nm, and a length of 14 μm. To our knowledge, these 120 nm resonators are the narrowest suspended structures ever fabricated via nanoimprinting. Device to device uniformity of resonant frequency was dictated by the uniformity of the tensile stress over the device layer. The 40 nm thick and 70 nm thick devices showed average resonant frequencies of 16.6±2 MHz, and 21.7±0.3 MHz, respectively. These devices were successfully employed as elements of arrays for the detection of a biological analyte. The biotin-streptavidin system was used for such purpose. The specific capture of streptavidin induced downward frequency shifts ranging from 100 to 300 kHz, corresponding to capture densities of roughly 1 to 5 molecules per 100 nm². Negative control experiments showed no net downward frequency shifts, demonstrating the specificity of the detection.

Citation Download Citation

Alex Janzen, Sommayyeh Poshtiban, Amit Singh, and Stephane Evoy "Fabrication of nanoresonator biosensing arrays using nanoimprint lithography," Journal of Micro/Nanolithography, MEMS, and MOEMS 11(2), 023013 (20 June 2012). https://doi.org/10.1117/1.JMM.11.2.023013

Published: 20 June 2012

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