Prostate ultrasound imaging has utilized B-mode, however recent success in 3D ultrasound tomography (3D-UT) in the presence of bone, indicate using it to augment other potentially harmful or expensive modalities in clinic. Several fresh whole prostates were excised/inserted into bespoke polyacrylamide gel phantoms within 30 minutes of prostatectomy and scanned in the QT imaging scanner. The speed of sound (SOS) map resulting from the 3D-UT was used to create the refraction corrected reflection image compounded over 360 degrees resulting in sub-mm resolution. Several lesions were correlated with rigid transformations via anatomic landmarks with clinical MRI and H&E stained whole sections by experts in MRI and whole sectioning. Lesions were pointed out all 3 modalities and compared for multiple lesions indicating proof of concept of unique visibility of prostate lesions in 3D-UT (also volography) ex-vivo.
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